Linked to more cancer, including breast cancer, in a large French study
The NutriNet-Santé study followed 105,260 French adults for more than seven years and tracked the colours in what they ate. People with higher intake of beta-carotene as an added colour (E160a) had 16% more cancer overall and 41% more breast cancer. This is one observational study. It is about the added colour, not carrots and other vegetables.
Among 105,260 French adults followed from 2009 to 2023, higher intake of beta-carotene as a food colour (E160a) was linked to a 16% higher risk of cancer overall and a 41% higher risk of breast cancer.
2026Observational study in peopleNutriNet-Santé cohort, Food colouring additives and cancer incidence, European Journal of Epidemiology; INRAE and Inserm press release
High-dose supplements raised lung cancer in smokers
Two large randomised trials, ATBC and CARET, found that smokers taking 20 to 30mg of beta-carotene a day had more lung cancer and more deaths than those on a dummy pill. CARET found 28% more lung cancer and 17% more deaths.
Male smokers given 20mg of beta-carotene a day for a median of six years had 18% more lung cancer than those on a dummy pill.
1994Randomised trial in peopleThe ATBC Cancer Prevention Study Group, New England Journal of Medicine
Smokers and asbestos workers given 30mg of beta-carotene plus vitamin A a day had 28% more lung cancer and 17% more deaths overall, and the trial was stopped 21 months early.
1996Randomised trial in peopleOmenn et al. (CARET study), New England Journal of Medicine
Pooling trials, beta-carotene supplements were linked to 24% more lung cancer in current smokers.
2008Review of many studiesTanvetyanon & Bepler, Cancer (Wiley / American Cancer Society)
Food colour amounts against supplement doses
In 2024 they advised smokers to avoid supplements containing it.
Reviewers set a condition: intake from the colour and supplements together should stay within what a normal diet gives, around 5 to 10mg a day.
2012Regulator reviewEFSA ANS Panel, Scientific Opinion on the re-evaluation of mixed carotenes (E160a(i)) and beta-carotene (E160a(ii)) as food additives, EFSA Journal 10(3):2593
Reviewers stated that smokers should avoid food supplements containing beta-carotene.
2024Regulator reviewEFSA NDA Panel, Scientific opinion on the tolerable upper intake level for preformed vitamin A and beta-carotene, EFSA Journal 22(6):8814
The international committee withdrew its daily limit
In 2019 the international committee withdrew its earlier daily limit for synthetic beta-carotene. A limit for the whole population has to cover heavy smokers, and the risk data from smokers made it impossible to set one level for everyone. The committee said the data needed may never be collected, for ethical reasons.
The international committee withdrew its earlier group limit for synthetic beta-carotene (up to 5mg per kg of body weight), because a limit covering the whole population must include heavy smokers, whose risk is raised.
2019Regulator reviewJECFA 87th Meeting, Joint FAO/WHO Expert Committee on Food Additives
Yellow skin at very high intakes
Eating a lot of beta-carotene for a long time can tint the skin yellow or orange, especially the palms, soles and around the nose. Unlike jaundice, the whites of the eyes stay white.
Carotenaemia happens with long-term high beta-carotene intake, roughly 20 to 50mg a day from food.
EstablishedDermNet NZ, Carotenoderma clinical review
Linked to more type 2 diabetes in a large French study
The NutriNet-Santé study followed 108,723 French adults for about 8 years and tracked the colours in the packaged food they ate. People who ate the most beta-carotene as an added colour (E160a) were 44% more likely to develop type 2 diabetes than those who ate little or none. It is about the added colour, not carrots and other vegetables. This is one observational study.
Among 108,723 French adults followed from 2009 to 2023, higher intake of beta-carotene as a food colour was linked to a 44% higher risk of type 2 diabetes (hazard ratio 1.44).
2026Observational study in peopleNutriNet-Santé cohort, Shah et al., Food Coloring Additives and Incidence of Type 2 Diabetes, Diabetes Care