Linked to heart disease in a large French study
In 2026 a NutriNet-Santé analysis of 112,395 French adults found people with more ascorbic acid from additives had 15% more heart and circulation disease. This is about the added preservative, not vitamin C from fruit and vegetables. These are observational studies.
Among 112,395 French adults followed from 2009 to 2024, higher intake of ascorbic acid as an additive was linked to a 15% higher risk of heart and circulation disease.
2026Observational study in peopleEuropean Heart Journal, NutriNet-Santé cohort (reported by INRAE)
Kidney stones at supplement doses
At gram-sized supplement doses, the body turns some vitamin C into oxalate. Very high intakes are linked to more kidney stones in people prone to them. The NHS advises keeping supplements below 1000mg a day.
Supplements of more than 1000mg of vitamin C a day can raise oxalate in urine and increase the risk of oxalate kidney stones, especially in people who have had them before.
ObservationalNHS, Vitamins and minerals: Vitamin C
European reviewers set an upper limit of 1000mg a day from all sources, because of stomach upsets and oxalate at higher doses.
2006Regulator reviewEFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), opinion on vitamin C
With E211 in fizzy drinks, it can form benzene
When ascorbic acid and sodium benzoate (E211) sit together in an acidic drink, especially with heat and light, they can react to form small amounts of benzene, which causes cancer. UK and EU law do not ban the pairing. The Food Standards Agency worked with makers to change recipes where it found benzene above 10 micrograms per litre.
Benzene can form in soft drinks containing both benzoic acid (E210 or E211) and ascorbic acid (E300) with heat and light. The FSA tested UK soft drinks and worked with industry to bring levels down.
2006Regulator testingFood Standards Agency, Survey of benzene in soft drinks
Benzene causes cancer in humans (IARC Group 1). It was first classified in 1982 and reviewed again in 2018.
2018EstablishedIARC Monographs Volume 120: Benzene