Regulatory safety evaluation
EFSA's Panel on Food Contact Materials, Enzymes and Processing Aids has evaluated multiple invertase preparations derived from Saccharomyces cerevisiae strains and found no grounds to restrict it at levels used in food. The enzyme is identical in function to the sucrase produced naturally in the human gut. EFSA has conducted strain-specific evaluations of invertase sources under the food enzymes regulation, with opinions published in 2023 and 2024.
EFSA evaluated the food enzyme beta-fructofuranosidase from non-genetically modified Saccharomyces cerevisiae strain INV and concluded no grounds to restrict it at the proposed use levels. Confirmed intended uses include manufacture of invert sugar syrups, baking, sucrose-based fermented beverages, and soft-centred confectionery including filled chocolates.
2023Regulatory reviewEFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), EFSA Journal 2023
EFSA evaluated the food enzyme beta-fructofuranosidase from non-genetically modified Saccharomyces cerevisiae strain CNCM I-3399 and concluded no grounds to restrict it at the proposed use levels in the same food manufacturing processes.
2024Regulatory reviewEFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), EFSA Journal 2024
Invertase was authorised as a food additive under EU Directive 95/2/EC and subsequently transitioned to regulation as a food enzyme under Regulation (EC) No 1332/2008; this transition reflected the reclassification of enzyme-based processing aids rather than any safety concern.
2008RegulatoryEuropean Commission, Regulation (EC) No 1332/2008 on food enzymes
Natural occurrence and human metabolism
Invertase is not a foreign substance to the body. The human small intestine produces sucrase-isomaltase, an enzyme that performs the same hydrolysis of sucrose. Invert sugar produced by the enzyme is therefore handled by normal carbohydrate metabolism pathways. People with hereditary fructose intolerance or sucrase-isomaltase deficiency are the groups for whom the resulting fructose or altered sugar profile is relevant.
Sucrase-isomaltase deficiency is a rare inherited condition in which the body cannot properly digest sucrose; ingestion of invert sugar (the product of invertase action) may worsen symptoms for affected individuals.
EstablishedOMIM / clinical gastroenterology literature