Asthma and airway reactions
Sulphites are among the most documented food triggers for asthma. When swallowed, sulphites produce sulphur dioxide gas in the acidic stomach environment; inhaling this during eating or drinking can cause rapid narrowing of the airways. Studies estimate that between 3% and 10% of people with asthma experience reactions when consuming sulphites. Those with steroid-dependent asthma or marked airway hyper-responsiveness face the highest risk. Reactions can range from coughing and wheezing to, rarely, life-threatening bronchospasm.
Between 3% and 10% of asthmatic subjects who consume sulphites experience sensitivity reactions, including wheezing, chest tightness and cough. Steroid-dependent asthmatics and those with marked airway hyper-responsiveness are at greatest risk.
2012ObservationalVally H, Misso NLA. Adverse reactions to the sulphite additives. Gastroenterology and Hepatology from Bed to Bench, PubMed PMID 24834193
The mechanism involves sulphur dioxide formation in the airways stimulating a cholinergic reflex causing bronchoconstriction; an IgE-mediated immune response has also been proposed, though the precise mechanisms remain incompletely understood.
Regulatory reviewAnaphylaxis UK: Sulphite Allergy fact sheet, anaphylaxis.org.uk
Neurotoxicity signals in animal and exposure studies
EFSA's 2022 re-evaluation of permitted sulphites (E220-E224 and E226-E228) identified new evidence from animal studies of neurotoxic effects, including a delayed response of nerve cells to stimuli detected via visual evoked potential testing. EFSA found its toxicity database insufficient to set an acceptable daily intake (ADI) and withdrew the previous temporary group ADI of 0.7mg SO2 equivalent per kg body weight per day. Using margin-of-exposure (MOE) calculations instead, EFSA found MOEs below its safety threshold of 80 for most population groups at the 95th percentile of intake, raising a safety concern for high consumers. These findings apply to the sulphite class as a whole and inform the risk profile of all sulphite compounds including E225.
Animal studies supporting sulphite-induced neurotoxic effects, including prolonged visual evoked potential latency, led EFSA to withdraw the temporary group ADI. MOEs at the 95th percentile of dietary exposure were below 80 for all population groups except adolescents, raising a safety concern.
2022Regulatory reviewEFSA Panel on Food Additives and Flavourings (FAF). Follow-up re-evaluation of sulphur dioxide (E 220), sodium sulphite (E 221), sodium bisulphite (E 222), sodium metabisulphite (E 223), potassium metabisulphite (E 224), calcium sulphite (E 226), calcium bisulphite (E 227) and potassium bisulphite (E 228). EFSA Journal 2022;20(11):7594
At high dietary exposure, estimated sulphite intakes for children exceeded the safety margin by up to 12.5% and for adults by up to 60%, based on margin-of-exposure analysis.
2022Regulatory reviewEFSA Journal 2022;20(11):7594 (as summarised in Foodnavigator, December 2022)
Thiamine (vitamin B1) destruction
Sulphite ions chemically cleave the thiamine molecule, breaking it down and reducing its availability in preserved food. In wine containing 400ppm sulphur dioxide, around half the added thiamine was destroyed within one week under laboratory conditions. This is a chemical degradation effect in the food product itself, not a direct effect on the body's thiamine stores from normal consumption at food-additive levels.
The sulphite ion cleaves the thiamine molecule by adding to its pyrimidinium ring, producing degradation products that no longer function as vitamin B1. In wine at 400ppm SO2, approximately 50% of thiamine was destroyed within one week at pH 3.5.
1984LabScott D. A mechanism for sulphite ion reacting with vitamin B1 and its analogues. Food Chemistry 1984;15(4):285-293. ScienceDirect
Regulatory status: not permitted in the UK or EU
E225 does not appear in Annex II of EU Regulation (EC) No 1333/2008 or on the UK FSA approved additives list. The permitted sulphites in UK and EU food law run E220, E221, E222, E223, E224, then jump to E226, E227 and E228. E225 was never granted authorisation under the current EU positive-list system and is absent from the UK's assimilated version of that regulation. Its use in food in Great Britain or Northern Ireland would be unlawful.
E225 (potassium sulphite) does not appear in Annex II of EU Regulation (EC) No 1333/2008 (as retained in UK law). The permitted sulphites are E220-E224 and E226-E228 only.
2024RegulatoryUK legislation.gov.uk: Regulation (EC) No 1333/2008, Annex II, version dated 2024-06-28
E225 is absent from the UK FSA approved additives and E numbers list.
RegulatoryUK Food Standards Agency. Approved additives and E numbers. food.gov.uk/business-guidance/approved-additives-and-e-numbers
The Miscellaneous Food Additives Regulations 1995 list sulphites E220-E224 and E226-E228; E225 does not appear.
1995RegulatoryThe Miscellaneous Food Additives Regulations 1995. legislation.gov.uk/uksi/1995/3187/made
Sulphite sensitivity: who reacts and how
Sulphite sensitivity does not involve the immune system in the same way as a classic food allergy, so most people who react are said to be intolerant rather than allergic. Symptoms include wheezing, hives, stomach pain, vomiting and worsening eczema. People with low levels of the enzyme sulphite oxidase may be less able to break down sulphites, causing them to accumulate and trigger airway tightening. Anaphylaxis from sulphites is very rare but has been reported.
Most sulphite reactions are sensitivity or intolerance responses not involving the immune system; symptoms range from respiratory (wheezing, tight chest) to skin (hives, worsening eczema) and gastrointestinal. A very small number of anaphylaxis cases have been reported.
Regulatory reviewAnaphylaxis UK. Sulphite Allergy fact sheet. anaphylaxis.org.uk/fact-sheet/sulphites/