The body does not digest it
Human digestive enzymes cannot break agar down, so it reaches the large bowel mostly whole, where gut bacteria ferment some of it. At higher intakes it adds bulk to stool and speeds things through. Some studies using large supplement doses noted a laxative effect, far above the amounts in food.
Agar is not broken down by the enzymes in saliva or the pancreas and passes into the large bowel, where gut bacteria partly ferment it into short-chain fatty acids.
2016Regulator reviewEFSA ANS Panel re-evaluation of agar (E 406) as a food additive, EFSA Journal
At very high supplement doses (around 180g a day in one older Japanese study), agar was linked to weight loss and lower blood sugar in overweight adults with type 2 diabetes, put down to its bulk and fullness effect.
2005Randomised trial in peopleMaeda et al., Diabetes, Obesity and Metabolism
Allergic reactions from food are rare
Agar comes from seaweed, not from common allergy-causing plants or animals. Recorded allergic reactions to agar in food are rare. People who handle large amounts of the dried powder at work have become sensitive to it, but that is not a food exposure concern.
Reviewers found no evidence that agar in food causes allergy in the general population at the levels used.
2016Regulator reviewEFSA ANS Panel re-evaluation of agar (E 406) as a food additive, EFSA Journal
Reviewers set no daily limit
European reviewers looked at agar in 2016 and set no numerical daily limit. They found no toxicity concern at the levels used, and no sign of cancer, DNA damage or harm to reproduction.
Reviewers raised no safety issue for the general population at estimated intakes of agar as an additive, and set no numerical daily limit.
2016Regulator reviewEFSA ANS Panel re-evaluation of agar (E 406) as a food additive, EFSA Journal