Reviewers found no DNA damage and set a shared daily limit
European reviewers looked at the sorbitan esters, E491 to E495, together. None damaged DNA in standard lab tests. They set a shared daily limit of 10mg per kg of body weight. Their estimates of what people eat, including children who eat the most, did not go over it at permitted use.
Sorbitan esters did not damage DNA in a set of lab and animal tests. Reviewers set a shared daily limit of 10mg per kg of body weight.
2015Regulator reviewEFSA ANS Panel, re-evaluation of sorbitan esters (E491-E495)
Estimated intake of sorbitan esters in Europe stayed under the shared daily limit, even for children who eat the most, when foods held the most the law allows.
2015Regulator reviewEFSA ANS Panel, re-evaluation of sorbitan esters (E491-E495)
Most of it is broken down into sorbitol and a common fat
The body absorbs little of it whole. Digestive enzymes split part of it into sorbitol and stearic acid, both ordinary parts of the diet. The rest passes through mostly unabsorbed. At the amounts used in food, studies found no build-up in the body.
Animals fed high doses, far above what people eat from permitted uses, showed no harm to organs or body weight.
2015Animal studyEFSA ANS Panel, re-evaluation of sorbitan esters (E491-E495)