Formation of toxic by-products: chlorite and chlorate
When chlorine dioxide reacts with food components or water it breaks down to form chlorite and chlorate ions. Both have been linked to adverse effects on red blood cells at higher exposures, and chlorate is under ongoing regulatory scrutiny as a contaminant in fruit and vegetables treated with chlorinated water.
Chlorate, a breakdown product of chlorine dioxide, has been found as a residue in fruit and vegetables treated with chlorinated wash water. EFSA concluded that current dietary exposure to chlorate may exceed the tolerable daily intake for some population groups, including infants.
2015Regulatory reviewEFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Journal
Chlorite, another breakdown product, causes haemolytic anaemia in animal studies at sufficient doses by oxidising haemoglobin.
2000AnimalUS EPA Integrated Risk Information System, chlorite assessment
Not authorised in UK and EU food
Chlorine dioxide has never been included in the EU positive list of permitted food additives (Annex II of Regulation 1333/2008). The UK carried this prohibition into retained law after Brexit. The flour bleaching uses that once existed in some countries were not brought into the EU system because regulators were not satisfied that the safety case had been established for food-grade use.
Chlorine and chlorine dioxide are not permitted flour treatment agents in the European Union. Use of chlorine, bromates, and peroxides for flour treatment is prohibited under EU food additives legislation.
2008RegulatoryEuropean Commission, Food Improvement Agents Regulation; EU Regulation 1333/2008 Annex II
The UK Bread and Flour Regulations 1998 prohibit the use of flour bleaching agents including chlorine gas and chlorine dioxide in bread and flour sold in the UK.
1998RegulatoryThe Bread and Flour Regulations 1998 (SI 1998/141), UK FSA
Dangers of 'Miracle Mineral Solution' containing chlorine dioxide
Chlorine dioxide has been marketed in some countries as a dietary supplement under names including 'Miracle Mineral Solution' (MMS) and 'CD Protocol'. Regulators in the UK, US, and EU have explicitly warned against consuming these products, which generate chlorine dioxide when mixed. Reported adverse effects in people who consumed them include severe nausea, vomiting, diarrhoea, and dangerous drops in blood pressure.
The UK Food Standards Agency has issued warnings that drinking solutions containing sodium chlorite that generate chlorine dioxide is potentially dangerous and the products are not authorised food additives.
2019RegulatoryUK Food Standards Agency, Miracle Mineral Solution safety warning
The US FDA warned that Miracle Mineral Solution products release chlorine dioxide and that drinking them can cause severe vomiting, diarrhoea, dangerous drops in blood pressure, and acute respiratory failure.
2019RegulatoryUS Food and Drug Administration, MMS safety alert