Dietary exposure is negligible
Because propane is a gas at room temperature, it evaporates almost entirely when an aerosol is used. The EFSA Panel on Food Additives concluded that dietary exposure through permitted food uses is extremely low or negligible. No numerical acceptable daily intake was set, because a quantitative exposure assessment was considered unnecessary given the physicochemical properties and the very low residues in food.
The EFSA Panel concluded that use of propane (E 944) as a food additive at currently permitted uses and levels does not raise a safety concern, and that dietary exposure is extremely low or negligible based on its physicochemical properties.
2025Regulatory reviewEFSA Panel on Food Additives and Flavourings, EFSA Journal 23(1):e9203
The 1,3-butadiene impurity
Commercial propane can contain traces of 1,3-butadiene, a substance classified by IARC as a Group 1 human carcinogen linked to leukaemia in workers with prolonged occupational exposure. Under the CLP Regulation (EC) No 1272/2008, 1,3-butadiene carries a harmonised classification as a Category 1A carcinogen and a Category 1B germ cell mutagen; ECHA considers it a non-threshold carcinogen. EU and UK specifications cap the 1,3-butadiene impurity in food-grade propane at no more than 0.1% by volume, in line with the CLP Regulation limit for gases containing this impurity. EFSA concluded that because 1,3-butadiene shares the same high volatility as propane, it also evaporates under permitted use conditions, resulting in negligible dietary exposure. EFSA did flag a data gap: manufacturers provided no information on their production methods, leaving uncertainty about whether other unlisted impurities might be present.
1,3-Butadiene is classified as carcinogenic to humans (IARC Group 1) on the basis of sufficient evidence of an increased risk for leukaemia in occupationally exposed workers.
2008RegulatoryIARC Monographs on the Identification of Carcinogenic Hazards to Humans, Volume 100F (1,3-Butadiene section)
According to the CLP Regulation (EC) No 1272/2008, 1,3-butadiene is classified as a Category 1A carcinogen and a Category 1B germ cell mutagen. ECHA considers 1,3-butadiene to be a non-threshold carcinogen. The same classifications apply to butane and isobutane when containing 0.1% or more of 1,3-butadiene.
2025Regulatory reviewEFSA Panel on Food Additives and Flavourings, EFSA Journal 23(1):e9203
EU specifications limit 1,3-butadiene in food-grade propane, butane and isobutane to not more than 0.1% v/v. EFSA found that, given the high volatility of 1,3-butadiene, dietary exposure from its presence as an impurity in food-additive propane is negligible under permitted use conditions.
2025Regulatory reviewEFSA Panel on Food Additives and Flavourings, EFSA Journal 23(1):e9203
EFSA identified a data gap: no manufacturer provided information on production methods for food-grade propane, butane or isobutane, leaving uncertainties about the potential presence of impurities beyond 1,3-butadiene that are not listed in current EU specifications.
2025Regulatory reviewEFSA Panel on Food Additives and Flavourings, EFSA Journal 23(1):e9203
Inhalation during aerosol use
When a food aerosol is sprayed, some propane gas is released into the surrounding air. EFSA assessed this route and concluded that inhalation exposure during normal use is not toxicologically relevant for the food-additive safety assessment. Animal inhalation studies identified no-observed-adverse-effect concentrations in the range of 3,000 to 12,000 parts per million, concentrations far above anything a consumer would encounter from a brief kitchen spray.
Animal inhalation studies for the C3 to C4 alkanes found no-observed-adverse-effect concentrations of 3,000 to 12,000 ppm. EFSA concluded that inhalation from food use is not toxicologically relevant for the consumer safety assessment of these food additives.
2025Regulatory reviewEFSA Panel on Food Additives and Flavourings, EFSA Journal 23(1):e9203