Gastrointestinal effects at realistic dietary amounts
Polyglycitol syrup is a polyol: it is only partially absorbed in the small intestine. The unabsorbed portion draws water into the gut by osmosis and is fermented by colonic bacteria, producing gas. EFSA found in 2009 that estimated dietary exposure at the proposed use levels was close to the doses at which gastrointestinal disturbances have been observed in humans. For this reason the EU and UK require a 'laxative' warning on products containing it.
EFSA found the toxicological data on polyglycitol syrup were insufficient to set a numerical ADI, and noted that estimated dietary exposure was close to levels associated with gastric disturbance in humans.
2009Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), Scientific Opinion on the use of Polyglycitol Syrup as a food additive, EFSA Journal
For polyols as a class, gastrointestinal effects including osmotic diarrhoea and bloating are the primary adverse outcomes in humans at intakes of roughly 20-30g per day, though individual thresholds vary considerably.
2009ObservationalGrabitske & Slavin, Journal of the American Dietetic Association
No ADI established: what that means
When a regulator cannot set an Acceptable Daily Intake it does not automatically mean the additive is harmful. In this case EFSA concluded there was no indication of a toxicological safety concern at the proposed uses, but the evidence base was thin enough that a numerical upper limit could not be derived. The laxative labelling requirement acts as the practical consumer-facing control in lieu of a formal ADI.
EFSA's ANS Panel stated that toxicological data were insufficient to establish an ADI but found no indication of a safety concern based on the available evidence for the proposed food uses.
2009Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), Scientific Opinion on the use of Polyglycitol Syrup as a food additive, EFSA Journal
Glycaemic and dental considerations
Because polyglycitol syrup is poorly absorbed it raises blood glucose far less than sucrose, which is why it appears in products marketed to people managing blood sugar. It is also non-cariogenic, meaning it does not feed the bacteria that cause dental cavities. These properties are well established across the polyol class.
Sugar alcohols including the components of polyglycitol syrup (sorbitol, maltitol, hydrogenated oligosaccharides) are non-cariogenic and produce attenuated glycaemic responses compared with sucrose.
2011RegulatoryEFSA, Scientific Opinion on the substantiation of health claims related to sugar alcohols and maintenance of tooth mineralisation