Linked to heart attack and stroke in 2023
A large 2023 study found that people with more erythritol in their blood were about twice as likely to have a heart attack or stroke over the next three years. The researchers also showed in lab tests that erythritol makes platelets stickier, which could help clots form. This is a link, not proof of cause. The people studied were already at higher heart risk, and people who eat more processed sweet food may have higher erythritol and poorer health for other reasons.
In more than 1,000 heart patients followed for three years, those with the highest blood erythritol had roughly twice the risk of heart attack, stroke or death compared with those with the lowest.
2023ObservationalWitkowski et al., Nature Medicine
Adding erythritol to blood in the lab, at levels like those after a normal serving, made platelets clump and stick more, which could raise the risk of clots.
2023Lab studyWitkowski et al., Nature Medicine
The link was repeated in two separate groups, one in the US and one in Europe, pointing the same way.
2023ObservationalWitkowski et al., Nature Medicine
Large amounts loosen the bowels
Unlike most polyols, erythritol is almost all absorbed before it reaches the large bowel, so there is much less of the wind and bloating that comes with sorbitol or maltitol. But above roughly 50g at once in adults, some reaches the bowel and causes loose stools and diarrhoea. European reviewers based their daily limit on this effect.
European reviewers set a daily limit of 0.5g per kg of body weight, based mainly on the laxative effect rather than any toxic effect.
2023Regulator reviewEFSA ANS Panel, EFSA Journal
In human studies, single doses of about 50g or more in adults caused loose stools. Lower doses were generally tolerated without stomach symptoms.
1999Randomised trial in peopleArrigoni et al., Regulatory Toxicology and Pharmacology
It does not raise blood sugar
The body does not turn erythritol into glucose, and its glycaemic index is zero. Trials in people with and without type 2 diabetes show it does not raise blood sugar or insulin, which is why it became popular in diabetic and keto products. The 2023 heart findings suggest that having no effect on blood sugar does not mean having no effect on the blood.
Erythritol has a glycaemic index of zero and did not raise insulin in clinical studies, unlike polyols the body partly breaks down.
1994Randomised trial in peopleNoda et al., European Journal of Clinical Nutrition
It does not rot teeth
Mouth bacteria do not ferment erythritol, so it does not cause tooth decay. Some studies suggest it may even cut the bacteria behind decay, though how much that matters in normal use is still being studied.
Sweets with erythritol reduced Streptococcus mutans, the main decay bacterium, in plaque and saliva compared with xylitol and sorbitol in a randomised trial in children.
2005Randomised trial in peopleMakinen et al., Caries Research