Enzyme-treated starches are digested like ordinary dietary starch: broken down to glucose in the small intestine and absorbed. The enzymatic pre-treatment during manufacturing does not alter how the body processes the final product. No adverse metabolic signals have emerged from the research literature.
The EFSA 2017 re-evaluation of modified starches (EFSA Journal 4911) covered E1404, E1410, E1412, E1413, E1414, E1420, E1422, E1440, E1442, E1450, E1451 and E1452. E1405 was not within the scope of that opinion, reflecting its absence from Annex II of Regulation 1333/2008 as a standalone listed additive. The broader scientific literature on enzymatically modified starches shows normal starch-digestion metabolism with no toxicological signals.
2017Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), EFSA Journal 2017;15(10):4911