Toxicology and animal studies
Feeding studies in rats and dogs conducted in the 1960s and 1970s found no adverse effects at the doses tested. Gum ghatti is not genotoxic in standard assays and has not been assigned an IARC carcinogen classification. No reproductive or developmental toxicity has been identified in the available literature. The dataset is limited compared to more widely used gums such as guar (E412) or locust bean gum (E410).
Subchronic and chronic feeding studies in rats found no treatment-related adverse effects at the doses tested; a no-observed-adverse-effect level was established but the studies are old and conducted to pre-modern standards.
2003AnimalUS FDA GRAS Notice GRN 000119, submitted by TIC Gums
Gum ghatti was not found to be genotoxic in the standard battery of in vitro tests assessed as part of the GRAS determination.
2003LabUS FDA GRAS Notice GRN 000119
Regulatory history and limited EU/UK approval
Unlike most E4xx thickeners and gums, gum ghatti does not appear in the main permitted food additives list used in the UK (assimilated EU Regulation 1333/2008, Annex II). This means it cannot lawfully be added to food sold in Great Britain under the current retained framework. Its E-number designation exists but it is not an actively approved additive in the UK or EU food supply. The US FDA accepted a GRAS notice for specific uses in beverages and other foods.
E419 does not appear in the UK Food Standards Agency approved additives list derived from assimilated EU Regulation 1333/2008, indicating it is not a currently permitted food additive in the UK.
RegulatoryUK Food Standards Agency, Approved Additives and E Numbers (food.gov.uk)
The US FDA accepted a GRAS notice for gum ghatti at use levels up to 0.2% in non-alcoholic beverages and beverage bases, salad dressings, processed cheese and other food categories.
2003RegulatoryUS FDA GRAS Notice GRN 000119