Regulatory absence, not toxicity
E446 does not appear on the UK Food Standards Agency approved additives list or in the current EU Annex II permitted food additives under Regulation 1333/2008. The consolidated text of Regulation 1333/2008 (as of December 2024) confirms the Annex II list progresses directly from E445 (glycerol esters of wood rosins) to E450 (diphosphates), with no E446 entry. The reason for its absence is not a specific documented safety ban but rather a lack of current authorisation. This means UK and EU food manufacturers cannot legally use it. No published EFSA safety opinion on E446 as a standalone entry is on record in recent evaluations.
E446 succistearin does not appear in the UK FSA list of approved additives and E numbers.
2024RegulatoryUK Food Standards Agency, Approved Additives and E Numbers (food.gov.uk)
Annex II of EU Regulation 1333/2008 sets the Union list of permitted food additives; E446 is not listed. The consolidated text confirms the list moves from E445 directly to E450, with no E446 entry. Article 30 of Regulation 1333/2008 states that 'food additives and uses which are no longer needed shall not be entered in Annex II.'
2024RegulatoryEuropean Commission, consolidated Regulation (EC) No 1333/2008, EUR-Lex CELEX:02008R1333-20241216
Chemistry and metabolism of succinylated glycerides
Succistearin is structurally similar to other food-grade emulsifiers in the glyceride ester family (such as E471 mono- and diglycerides, E472 their acetic, lactic, citric, and tartaric acid esters). Succinic acid itself is a natural metabolic intermediate in the citric acid (Krebs) cycle in human cells. When ingested, succinylated glycerides are expected to hydrolyse in the gut to their component fatty acids and succinic acid, both of which are normal metabolites. No specific toxicological concern has been raised about succistearin itself in published literature at food-relevant levels.
Succinic acid is an endogenous intermediate of the citric acid cycle and is considered a normal component of human metabolism.
Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), general background on organic acids used as food additives