It can carry trans fat
DATEM made from partly hydrogenated oils can contain industrial trans fat, which raises LDL cholesterol and lowers HDL cholesterol. The WHO wants industrial trans fat removed from food worldwide. Many makers now use fats that are not hydrogenated, which cuts or removes the trans fat, but it varies by supplier and the label will not tell you which you are getting.
Industrial trans fats raise LDL cholesterol, lower HDL cholesterol, and are linked to more coronary heart disease. The WHO called for them to be removed from food supplies by 2023.
2018EstablishedWHO REPLACE package / WHO Global Trans Fat Elimination
European reviewers noted that the fats in DATEM, including any trans fat, depend on the starting fat, and flagged this as relevant to how much people take in.
2020Regulator reviewEFSA FAF Panel, EFSA Journal, re-evaluation of E472a-f
Linked to type 2 diabetes in a large French study
The NutriNet-Santé study asked more than 100,000 French adults to record everything they ate, then followed their health for about 7 years. People who ate more DATEM were more likely to develop type 2 diabetes. This shows a link, not proof that DATEM causes diabetes, and the researchers called for more research.
Among 104,139 French adults followed for an average of 6.8 years, each extra 100mg of DATEM (E472e) eaten a day was linked to a 4% higher risk of type 2 diabetes.
2024Observational study in peopleSalame et al., The Lancet Diabetes & Endocrinology, NutriNet-Santé cohort
Reviewers could not set a number and flagged gaps
European reviewers looked at E472a to E472f together in 2020. They said the toxicity data were limited. They set no numerical daily limit for the fat and glycerol it breaks down into, which are normal parts of food, but flagged gaps in the data on the acetic and tartaric acid parts at high doses. That is a caution, not a clearance.
Reviewers could not set a numerical daily limit for E472e. They set none for the parts that are normal in the diet, but flagged data gaps for the acid-bound parts at high intakes.
2020Regulator reviewEFSA FAF Panel, EFSA Journal 18(3):e06032, re-evaluation of E472a-f
The body breaks it back into its parts
In the gut DATEM is split back into glycerol, fatty acids, tartaric acid and acetic acid, all normal parts of food. At the amounts in bread, reviewers did not see these parts as a separate hazard beyond the trans fat question above.
DATEM is split during digestion into glycerol, fatty acids, tartaric acid and acetic acid. Reviewers noted these are normal parts of the diet or the body and raised no specific issue about them at normal food amounts.
2020Regulator reviewEFSA FAF Panel, EFSA Journal 18(3):e06032