Chemical inertness and absence of biological interaction
Helium is chemically inert: it has a full outer electron shell, forms no compounds, and passes through the body without reacting with tissues, enzymes, or DNA. No toxicological studies exist because the substance has no reactive chemistry to evaluate. EFSA's 2024 panel concluded that its physicochemical properties alone are sufficient to confirm it poses no concern from dietary exposure.
EFSA's re-evaluation panel concluded that helium used as a food additive does not raise a safety concern, citing its chemical inertness as a noble gas and that no toxicological data are needed or available.
2024Regulatory reviewEFSA Panel on Food Additives and Flavourings (FAF), EFSA Journal
Impurity uncertainty noted by EFSA
The 2024 EFSA review noted one honest gap: no data were provided on what impurities might be present in food-grade helium above the 99.0% purity floor, or whether any of those impurities could pose a concern. The panel judged this gap as minor given the inert nature of the parent substance, but recorded it as unresolved.
No information was available on the potential presence of impurities of toxicological concern in food-grade helium; the EFSA panel noted this as a data gap.
2024Regulatory reviewEFSA Panel on Food Additives and Flavourings (FAF), EFSA Journal
Practical absence from food supply
EFSA's 2024 survey found that no business operators in the EU reported actually using helium in food products, and a search of labeled products found none containing E939. Its authorisation appears to be precautionary or historic rather than a reflection of current commercial practice.
A database search for products labeled with E939 returned no results, and no use data were submitted during EFSA's call for information on helium as a food additive.
2024Regulatory reviewEFSA Panel on Food Additives and Flavourings (FAF), EFSA Journal