Ozone depletion and the Montreal Protocol ban
CFC-12 has an ozone depletion potential of 1.0, the benchmark against which all other CFCs are measured. When released into the upper atmosphere, it breaks down and releases chlorine atoms that catalyse ozone destruction. This environmental hazard, not direct human toxicity at food-use levels, drove its global phase-out. Developed countries phased out production by 1996 under the Montreal Protocol; developing countries followed by 2010.
CFC-12 has the highest ozone destruction potential of all common refrigerant gases and was phase out globally under the Montreal Protocol on Substances that Deplete the Ozone Layer.
1987RegulatoryUnited Nations Environment Programme, Montreal Protocol on Substances that Deplete the Ozone Layer
Toxicology at high concentrations
At the trace levels historically associated with food use, no adverse human health effects were established. At high atmospheric concentrations (occupational or industrial exposure) the substance can sensitise the heart to arrhythmias, reduce respiratory capacity, and cause central nervous system depression. These effects are not relevant to the residual contact a consumer would have had with food frozen using the gas, as virtually all gas dissipates before consumption.
At high inhalation concentrations, CFC-12 sensitises the myocardium to adrenaline-induced arrhythmias and produces CNS depression. Effects are concentration-dependent and not observed at trace environmental levels.
1984AnimalNational Academies of Sciences, Emergency and Continuous Exposure Limits for Selected Airborne Contaminants, Chapter: Fluorocarbon 12
Rat and dog feeding studies with CFC-12 used as a food freezant found an acceptable daily intake of up to 1.5mg/kg body weight with no observed adverse effect at that level.
AnimalJoint FAO/WHO Expert Committee on Food Additives (JECFA)