EFSA re-evaluation: no identified safety concern
In 2017, the European Food Safety Authority re-evaluated all modified starches permitted in the EU, including E1420. At extremely high doses in animal studies, no treatment-related effects relevant to human health were observed. EFSA concluded there was no safety concern for the general population at reported use levels and saw no need to set a numerical acceptable daily intake.
EFSA's ANS Panel found no adverse effects in rats fed modified starches up to very high doses and concluded no safety concern exists at reported food use levels. It set no numerical ADI.
2017Regulatory reviewEFSA ANS Panel, EFSA Journal, re-evaluation of modified starches E1404-E1452
Digestion and metabolism
Acetylated starch is digested in the gut much like ordinary starch. The acetyl groups are hydrolysed during digestion and absorbed as acetate, a normal product of carbohydrate metabolism also produced by gut bacteria. There is no accumulation in the body and no metabolite with a known toxic profile at food intake levels.
Modified starches are hydrolysed to glucose and acetate during digestion; neither metabolite raises a toxicological concern at food intake levels.
2017Regulatory reviewEFSA ANS Panel, EFSA Journal, re-evaluation of modified starches E1404-E1452
Source plant allergen consideration
The starch itself is highly purified and the protein content is very low, meaning the source plant (wheat, maize, potato, rice, tapioca) rarely poses a practical allergen risk via the starch fraction. UK food labelling law does, however, require declaration of wheat-derived starch because wheat is a listed allergen, even if the residual protein is minimal.
Highly purified starches derived from allergenic grains such as wheat contain negligible residual protein and are not considered to trigger allergic reactions in most sensitised individuals, though labelling law in the UK and EU requires declaration of the wheat origin.
RegulatoryUK Food Information Regulation (FIR) 2014, Annex II allergen labelling requirements