What the animal studies found
European reviewers looked at paprika extract in 2015, including a 13-week study and a long-term cancer study in rats. They found no DNA damage, no effects on reproduction and no cancer at any dose tested, and set a daily limit of 24mg per kg of body weight. The international committee set a lower limit, measured differently.
Reviewers found no DNA damage in bacterial and mammalian cell tests on a commercial paprika extract.
2015Regulator reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), Scientific Opinion on the re-evaluation of paprika extract (E 160c) as a food additive, EFSA Journal 2015, volume 13, 4320
A long-term study in rats found no cancer. Reviewers set a daily limit of 24mg per kg of body weight, equal to 1.7mg of carotenoids per kg.
2015Regulator reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), Scientific Opinion on the re-evaluation of paprika extract (E 160c) as a food additive, EFSA Journal 2015, volume 13, 4320
The international committee set a daily limit of up to 1.5mg per kg of body weight, measured as total carotenoids, a more cautious figure than the European one.
2014Regulator reviewJECFA (Joint FAO/WHO Expert Committee on Food Additives), monograph on paprika extract
Allergy to peppers
Paprika extract comes from sweet peppers, and people truly allergic to peppers or paprika can react to it. Case reports describe hives, hay fever symptoms and anaphylaxis after eating paprika-containing food. Pepper allergens can also cross-react with latex and some pollens. Pepper allergy is uncommon, but breathing in spice dust is a known cause of allergy in food workers.
Case reports describe anaphylaxis after eating paprika, with positive skin tests and antibodies to sweet pepper proteins.
ObservationalNguyen et al., A Dash of Danger: A Rare Case of Paprika Anaphylaxis, Brown Medicine case report
Bell pepper shares allergens with latex, which contributes to latex-fruit syndrome in people allergic to latex.
2004Lab studyWagner et al., Characterization of cross-reactive bell pepper allergens involved in the latex-fruit syndrome, Clinical and Experimental Allergy
Antioxidant activity in the lab
In lab and cell studies, capsanthin and capsorubin act as antioxidants, and some animal work hints at potential benefits. These come from isolated cells and animals, not people, and the amount in a food colour is very small. No health claim can be made from this.
Capsanthin and capsorubin showed stronger antioxidant activity than beta-carotene in lab tests.
2021Lab studyKhalil et al., Biological Activities of Paprika Carotenoids, Capsanthin and Capsorubin, PubMed PMID 33783751