Studies link them to better cholesterol and heart health
Trials giving people anthocyanin supplements or anthocyanin-rich berries have found lower LDL cholesterol, higher HDL cholesterol, lower blood fats and fewer signs of inflammation. Studies following large groups found people who eat more anthocyanins have less coronary heart disease. Blood pressure results are mixed. Most trials used concentrated supplements, at far more than a food colour adds.
Pooling 44 randomised trials, purified anthocyanin supplements lowered LDL cholesterol by 5.43mg/dL, raised HDL cholesterol by 11.49mg/dL and lowered triglycerides by 6.18mg/dL compared with control.
2021Review of many studiesXu et al., Frontiers in Nutrition, PMC8714924
In the 15 cohort studies in the same review, higher anthocyanin intake was linked to 17% less coronary heart disease (RR 0.83) and 27% less heart and circulation disease overall (RR 0.73).
2021Review of many studiesXu et al., Frontiers in Nutrition, PMC8714924
Pooling 32 randomised trials (1,491 people), anthocyanin supplements lowered fasting blood sugar, HbA1c, total cholesterol and LDL cholesterol, with no clear effect on blood pressure.
2022Review of many studiesAdvances in Nutrition, S2161-8313(22)00801-8
Most reach the bowel, where bacteria break them down
Little of what you eat is absorbed whole in the small intestine. Most reaches the large bowel, where bacteria break it into smaller compounds. In a review of rodent studies, diets rich in anthocyanins shifted the balance of gut bacteria and raised short-chain fatty acids. These findings come from animals, and evidence in people is limited.
Across 34 rodent studies, anthocyanin diets clearly lowered the ratio of Firmicutes to Bacteroidetes bacteria and raised acetic, propionic and butyric acid. All studies were in animals, so how this applies to people is uncertain.
2023Animal studyKapoor et al., Scientific Reports, PMC9889808
Only 1 to 2% of anthocyanins eaten reach the blood unchanged. Gut bacteria turn most of them into smaller compounds, which may be behind the effects seen.
2023ObservationalBisaccia et al., PMC10525277
Too little safety data to set a limit
When European reviewers looked at anthocyanins as an additive in 2013, they found too little toxicity data to set a numerical daily limit. They noted that intake from the additive was higher than from normal food, and asked for better data. For extracts made with water from edible fruit and vegetables, they did not expect a problem at current use. For other sources or methods, they could not check.
Reviewers found the toxicity data for anthocyanins (E163) too thin to set a numerical daily limit, and recommended requiring better data on what the extracts contain and on toxicity.
2013Regulator reviewEFSA ANS Panel, EFSA Journal 2013, volume 11, 3145
For anthocyanins extracted with water from edible fruit and vegetables, reviewers did not expect current use to raise a safety issue. For other sources or extraction methods, missing data meant they could not confirm this.
2013Regulator reviewEFSA ANS Panel, EFSA Journal 2013, volume 11, 3145