The gut breaks it down almost completely
In the gut, E475 is broken down almost entirely into its parts, polyglycerols and fats. Very little gets into the blood whole. The fats join the body's normal fat handling, and the polyglycerols are mostly passed out. This quick and near-complete breakdown was a key reason reviewers set no numerical daily limit.
Very little whole polyglycerol ester is absorbed from the gut. It is quickly and almost fully split into polyglycerols and fats before absorption.
2017Regulator reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), re-evaluation of E 475
No harm found at any dose tested in animals
Short, medium and long-term animal feeding studies found no harm at any dose tested, and standard tests found no DNA damage. European reviewers found no dose that caused harm, so they did not think a numerical daily limit was needed.
Short-term, medium-term and long-term animal studies found no harm from polyglycerol esters at any dose tested.
2017Animal studyEFSA Panel on Food Additives and Nutrient Sources (ANS), EFSA Journal
Lab and animal tests found no evidence of DNA damage.
2017Lab studyEFSA Panel on Food Additives and Nutrient Sources (ANS), EFSA Journal
Reviewers asked for tighter limits on manufacturing impurities
A 2022 European follow-up looked not at the additive but at contaminants that can come from making it: heavy metals (arsenic, lead, mercury and cadmium), erucic acid, and oil-refining contaminants called 3-MCPD and glycidyl esters. It recommended tighter limits on all of them. This is about manufacturing quality, not the emulsifier itself.
Reviewers recommended lower limits for arsenic, lead, mercury and cadmium in E475, and new limits for erucic acid, 3-MCPD and glycidyl esters, based on tests of commercial products.
2022Regulator reviewEFSA Panel on Food Additives and Flavourings (FAF), follow-up re-evaluation of E 475, EFSA Journal