Aluminium exposure and the tolerable weekly intake
EFSA set a tolerable weekly intake (TWI) of 1 mg aluminium per kilogram of body weight per week in 2008, covering all dietary aluminium sources combined. When EFSA re-evaluated the aluminium sulphate group (E520-523) in 2018, it found that total aluminium intake from food in European populations, particularly children, can approach or exceed this TWI when all sources are added together. The contribution from food additives such as E522 is a fraction of this total, but it is not negligible.
EFSA established a tolerable weekly intake of 1 mg aluminium per kg body weight per week, based principally on neurodevelopmental effects observed in animal studies.
2008Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), EFSA Journal
In the 2018 re-evaluation of aluminium sulphates (E520-523), EFSA confirmed that the TWI remained 1 mg Al/kg bw/week and noted that some population groups, particularly children, may exceed it when all dietary aluminium sources are considered together.
2018Regulatory reviewEFSA ANS Panel re-evaluation of aluminium sulphates (E520-523) and sodium aluminium phosphate (E541), EFSA Journal 2018; 16(7):5372
Aluminium and the nervous system
Animal studies at higher aluminium doses have shown effects on the developing nervous system, including changes in behaviour and neurotransmitter levels. These findings informed the TWI. Human epidemiological data on dietary aluminium from food additives specifically are limited; most human research concerns aluminium from drinking water or occupational exposure at far higher levels.
Animal studies show neurotoxic effects at higher aluminium doses, including neurobehavioural changes in developing animals, which formed the primary basis for EFSA's TWI of 1 mg Al/kg bw/week.
2008AnimalEFSA ANS Panel, EFSA Journal 2008; 6(7):754
JECFA set a provisional tolerable weekly intake of 2 mg Al/kg bw/week in 2011, derived from a NOAEL of 30 mg/kg bw/day in a neurodevelopmental study with a 100-fold safety factor.
2011Regulatory reviewJECFA (Joint FAO/WHO Expert Committee on Food Additives), 73rd meeting
Aluminium accumulation in the body
Aluminium from food is poorly absorbed through the gut, typically less than 1% of ingested aluminium enters the bloodstream. However, absorbed aluminium is excreted slowly and can accumulate in bone and soft tissue with long-term exposure. People with impaired kidney function excrete it even more slowly and are considered a higher-risk group.
Gastrointestinal absorption of aluminium from food is low (generally below 1%), but aluminium that is absorbed is retained in bone, brain and other tissues and is eliminated slowly via the kidneys.
2018Regulatory reviewEFSA ANS Panel re-evaluation of aluminium sulphates, EFSA Journal 2018; 16(7):5372