Neurotoxicity from aluminium at sustained higher intake
Animal studies, mainly in rats, show that aluminium absorbed into the body crosses into the brain and causes nerve cell damage at sustained elevated doses. These findings are the scientific basis for the weekly intake limit set by European regulators. Human evidence for neurotoxicity from dietary aluminium at typical food levels is much weaker, but the limit was set conservatively on the animal data.
Animal studies show aluminium causes neurotoxicity at high sustained doses, including effects on nerve cell structure and function. EFSA used these data to set a group Tolerable Weekly Intake of 1 mg/kg body weight per week for total aluminium from all dietary sources.
2008Regulatory reviewEFSA Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) - Scientific Opinion on the safety of aluminium from dietary intake
In the 2018 re-evaluation of E520-523 and E541, EFSA found that these aluminium-containing food additives contribute to total dietary aluminium exposure. Exposure from these additives alone is small relative to the TWI, but they add to background aluminium from food, water, and other sources.
2018Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS) - Re-evaluation of aluminium sulphates (E 520-523) and sodium aluminium phosphate (E 541) as food additives. EFSA Journal 2018;16(7):5372
Total dietary aluminium exposure in the population
Aluminium enters the diet from natural levels in food and water, cookware, and multiple food additives including E523. EFSA's 2008 review found that some European consumers' total aluminium intake can approach or exceed the weekly limit when all these sources are combined. Children who eat relatively more processed or baked goods may face proportionally higher exposure per kilogram of body weight.
EFSA estimated that total dietary aluminium intake in some European population groups, including children at the high end of consumption, can reach or slightly exceed the Tolerable Weekly Intake of 1 mg/kg body weight per week when all food sources are combined.
2008Regulatory reviewEFSA AFC Panel - Scientific Opinion on the safety of aluminium from dietary intake. EFSA Journal 2008;754
Aluminium and Alzheimer's disease: association, not established cause
Some observational studies found higher aluminium levels in brain tissue of people with Alzheimer's disease. This generated public interest and concern, but decades of research have not established that dietary aluminium causes Alzheimer's. Regulators and mainstream scientific bodies have not classified aluminium as a cause of Alzheimer's; the association remains unresolved.
Epidemiological and neuropathological studies have reported elevated aluminium concentrations in brains of Alzheimer's patients, but these findings do not establish a causal relationship and remain contested in the scientific literature.
2008ObservationalEFSA AFC Panel - Scientific Opinion on the safety of aluminium from dietary intake. EFSA Journal 2008;754