Magnesium as a nutrient
Magnesium is an essential mineral involved in hundreds of enzymatic reactions in the body, including muscle and nerve function, blood sugar regulation, and bone development. At the small amounts present in food as an anti-caking agent, the contribution to daily magnesium intake is minimal. When used in supplements or fortified foods, the dose becomes nutritionally relevant.
Magnesium oxide has lower bioavailability than some other magnesium salts (such as magnesium citrate), meaning a smaller proportion of the mineral is absorbed from the gut.
2015Regulatory reviewEFSA NDA Panel opinion on magnesium
Laxative effect at high supplemental doses
At high doses, such as those found in medicinal magnesium oxide products, the compound draws water into the bowel and can cause loose stools or diarrhoea. This effect is well-documented in pharmaceutical contexts. The amounts used in food as an anti-caking agent are far below the doses that produce this effect, so it is not a practical concern from food use alone.
EFSA noted that magnesium intakes above approximately 250mg per day from supplemental sources can cause diarrhoea in some individuals; this threshold is not relevant to amounts from food additive use.
2021Regulatory reviewEFSA Scientific Opinion on the tolerable upper intake level of magnesium