Metabolism and body handling
Gluconate is a normal intermediate in human carbohydrate metabolism and is present naturally in many foods. When sodium gluconate is consumed, it is broken down to gluconic acid, which is metabolised via standard pathways or excreted in urine. No accumulation in tissues has been identified.
Gluconic acid and its salts are rapidly and completely metabolised in humans via normal carbohydrate pathways; no toxic metabolites are formed at dietary exposure levels.
Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS) - background assessment of glucono delta-lactone and gluconates
Regulatory toxicology assessment
Regulatory bodies that have reviewed gluconates have not set a numerical acceptable daily intake, concluding that intake from permitted food uses does not raise a toxicological concern. The substance has a long history of use in food and pharmaceutical manufacture.
The Joint FAO/WHO Expert Committee on Food Additives (JECFA) evaluated sodium gluconate and established 'not specified' as the ADI, meaning normal food use levels do not present a toxicological concern.
RegulatoryJECFA (Joint FAO/WHO Expert Committee on Food Additives)
Sodium gluconate is authorised as a food additive in Great Britain and the EU under assimilated Regulation (EC) No. 1333/2008 Annex II, with no numerical maximum level set for most permitted uses.
2020RegulatoryUK FSA Regulated Products Register; assimilated EU Regulation 1333/2008