Tartrate is handled by the kidneys, and at very high supplemental doses there is theoretical concern about oxalate or tartrate crystallisation in people already prone to kidney stones. Food-level intake is far below the doses studied. No clinical evidence links normal dietary exposure to kidney stone risk.
Tartaric acid is metabolised in the body; the kidney excretes tartrate, and at pharmacological doses animal studies have noted renal tubular effects, but these are not observed at dietary exposure levels.
2014Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS), Re-evaluation of tartaric acid (E334), sodium tartrates (E335), potassium tartrates (E336), potassium sodium tartrate (E337) and calcium tartrate (E354) as food additives