Metabolism and normal body handling
Tartaric acid and its salts, including calcium tartrate, are reviewed by EFSA as a group (E334 to E337 and E354). Tartrate is a normal metabolite found in fruit and wine and is handled through normal digestion. EFSA concluded that no numerical acceptable daily intake was necessary because intake from food is well within the range considered unremarkable. There are no genotoxicity signals in the published literature.
EFSA evaluated tartaric acid and tartrates (E334, E335, E336, E337, E354) as a group and found no evidence of genotoxicity or reproductive toxicity at relevant dietary exposure levels.
2020Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS)
Kidney stone consideration
Tartrate is excreted via the kidneys. People who form calcium oxalate kidney stones are sometimes advised to moderate their intake of high-oxalate and high-organic-acid foods, including foods rich in tartaric acid. This is a general dietary consideration and not specific to E354 as a food additive. There is no published evidence of a kidney risk from E354 at typical food additive use levels.
Tartaric acid is absorbed and excreted renally; high dietary tartrate is a recognised dietary variable in calcium stone risk discussions, though evidence at food-additive use levels is limited.
ObservationalGeneral nephrology literature; no specific E354 study