Nano-sized particles and the rules that do not cover them
Some of the particles in E551 as sold are smaller than 100 nanometres. The EU's legal description of E551 does not define or limit that part. In 2018 European reviewers called this a gap. In a 2024 follow-up they found the nano-sized particles have limited absorption from the gut and do not build up in the body, and asked for particle size and tighter limits on arsenic and lead to be written into the rules.
Reviewers found the legal description of E551 did not pin down particle size or rule out nanoparticles, and flagged this as a gap.
2018Regulator reviewEFSA ANS Panel, EFSA Journal 2018;16(1):5088
In a 2024 follow-up, reviewers raised no safety issue for any age group at reported use levels, found nano-sized particles poorly absorbed and not building up in the body, and recommended adding particle size to the rules.
2024Regulator reviewEFSA ANS Panel, EFSA Journal 2024;22(10):8880
The body takes up very little
Silicon dioxide is not a nutrient, and the gut takes up very little of it. What little reaches the blood is cleared by the kidneys in urine. Studies found no build-up in tissues at the amounts eaten as an additive.
Amorphous silica is very poorly absorbed in animal and human studies, and what is absorbed is quickly passed in urine. No build-up in tissue was seen at food-use amounts.
2018Regulator reviewEFSA ANS Panel, EFSA Journal 2018;16(1):5088
Not the silica dust that causes lung cancer
Breathing in crystalline silica dust, from cutting stone, concrete or quartz, causes silicosis and lung cancer. The silica in food is the non-crystal form and is swallowed, not breathed in. Reviewers treat the two as separate hazards, and the cancer classification for the dust does not cover the food form.
IARC classed breathed-in crystalline silica dust as causing lung cancer in humans (Group 1) in 1997, and confirmed it in 2012. The classification does not cover amorphous silica swallowed as a food additive.
2012Regulator reviewIARC Monographs Volume 68 (1997); confirmed in Volume 100C (2012)