Vitamin C activity
Despite its chemical resemblance to vitamin C, erythorbic acid has very little vitamin C bioactivity in the human body. Studies show it cannot meaningfully substitute for ascorbic acid in preventing scurvy or supporting collagen synthesis. It is metabolised differently and excreted more rapidly. Manufacturers chose it over vitamin C partly because it is cheaper to produce and performs well as an antioxidant without the added vitamin benefit.
Erythorbic acid has approximately 1/20th to 1/5th the vitamin C activity of ascorbic acid in standard bioassay models, meaning it cannot replace dietary vitamin C.
Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS)
Oxalate excretion and kidney stones
There is a theoretical concern that high intake of erythorbic acid may increase urinary oxalate excretion, because it can be metabolised to oxalic acid. For most people this is unlikely to be relevant at the amounts encountered in food. Individuals with a history of calcium oxalate kidney stones are sometimes advised to moderate intake of oxalate-generating compounds, though no specific guidance names erythorbic acid as a primary concern.
Like ascorbic acid, high-dose erythorbic acid can generate oxalate as a metabolic by-product, which is a recognised risk factor for calcium oxalate urolithiasis in susceptible individuals.
Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources (ANS)
Nitrite interaction in cured meat
In cured meats, erythorbic acid is added alongside sodium nitrite. It speeds up conversion of nitrite to the stable colour pigment, which incidentally reduces residual free nitrite in the final product. Whether this meaningfully alters the formation of nitrosamines, which are associated with increased bowel cancer risk, is debated. The relevant concern for regular cured-meat eating relates to the nitrite system overall rather than to erythorbic acid specifically.
Erythorbic acid accelerates the formation of nitrosomyoglobin from nitrite in cured meat, reducing residual nitrite levels in the final product.
2017RegulatoryEFSA Scientific Opinion on nitrites and nitrates
Processed meat consumption is classified as IARC Group 1 (causes colorectal cancer in humans), primarily attributed to the nitrite/nitrosamine chemistry in cured products, not to the antioxidants added alongside.
2015EstablishedIARC Monographs Volume 114