Sodium contribution from the additive
Like all sodium salts used as food additives, sodium adipate adds to total dietary sodium intake. At typical additive use levels the sodium contribution is small, but it is relevant for people already managing high dietary sodium. There is no concern unique to the adipate anion at normal food additive doses.
High dietary sodium intake is associated with raised blood pressure and increased cardiovascular risk; this applies to all sodium-containing ingredients, including sodium-salt food additives.
EstablishedNHS and SACN, Dietary Reference Values for Food Energy and Nutrients for the United Kingdom
Adipic acid group: regulatory safety review
The adipates (adipic acid and its sodium and potassium salts, E355-E357) have been evaluated by EFSA. The panel concluded that available data did not raise safety concerns at the levels used in food, though they noted limitations in older toxicological datasets. No ADI based on a toxicological endpoint was considered necessary, though some sources quote a group ADI of 5 mg/kg bodyweight per day derived from older JECFA work.
EFSA's food additives panel reviewed the adipate group and found no grounds to restrict it at typical food use levels, noting that adipic acid is a normal metabolic intermediate in humans.
2014Regulatory reviewEFSA Panel on Food Additives and Nutrient Sources Added to Food (ANS)
Adipic acid is an endogenous compound produced during normal fatty acid metabolism, which means the body has established pathways for handling the adipate anion.
RegulatoryJECFA (Joint FAO/WHO Expert Committee on Food Additives) monograph on adipic acid