Adipic acid metabolism
The body handles adipic acid through normal fatty acid metabolism pathways. At the levels present in food, it is metabolised and excreted without accumulating. Because potassium adipate dissociates in solution into adipate ions and potassium ions, the relevant biological exposure is to these common metabolites rather than to the additive as a compound.
Adipic acid is rapidly metabolised by mammals via beta-oxidation and the tricarboxylic acid cycle; no accumulation was observed in standard toxicological studies at dietary exposure levels.
Regulatory reviewWHO Food Additives Series / JECFA evaluation of adipic acid and its salts
Potassium intake
Potassium is an essential dietary mineral. The amounts added to food via E357 are small relative to normal dietary intake from fruit, vegetables and other sources, and would not represent a meaningful additional burden for healthy people. Very high potassium intakes are relevant only to people with kidney disease who already struggle to excrete potassium, which is why that group is flagged separately.
Adults with chronic kidney disease are advised to monitor dietary potassium intake from all sources, including potassium-containing food additives, because impaired kidneys cannot excrete excess potassium efficiently.
RegulatoryNHS: Eating well with chronic kidney disease